A new study shows that men who are trying to take Viagra or Cialis are more likely to experience a more severe type of heart disease, according to the new findings published today in theJournal of the American College of Cardiology.
The study, published online April 14 in the journalJAMA Internal Medicine, is based on the results of a recent study that looked at whether men who used an over-the-counter (OTC) version of Viagra (sildenafil citrate) or Cialis (tadalafil) were more likely to have a serious heart problem, compared with those who used the older medication.
The study involved a total of 7,081 men from the U. K. who were living in or working in London, U. K., or the U. S. A.
The study involved men who were prescribed an OTC version of Viagra or Cialis for erectile dysfunction (ED) for four weeks. The results were then analyzed using statistical methods to determine the relative risks of using the two medications in combination.
The men in the study were over 60 years old and had a body mass index (BMI) of 30 or more. All were taking at least one of the medications used in the study.
Researchers found that men who took Viagra were 69 percent more likely to experience heart disease than those who took Cialis or tadalafil, the researchers said.
“Viagra and Cialis were the most effective medications used in this study, but the combination of these medications increased the risk for a severe type of heart disease by 20 percent," said lead author and director of the Cardiovascular Epidemiology and Endocrinology Program at the U. Department of Veterans Affairs. "These results suggest that taking a combination of medications may be a safer alternative to traditional OTC medications."
Viagra and Cialis are both OTC drugs, said Dr. Peter Zuckerman, the lead author of the study, and co-author of the original paper.
“There is a lot of confusion about whether an individual is more at risk of a severe form of cardiovascular disease, or whether it is the result of a different mechanism," he said. "The question is, is there really an association between taking these two medications?”
Dr. Zuckerman said he does not know how much of the study’s findings might have come from a different study. But he said it's possible that Viagra and Cialis were taken together in combination, and that they had similar side effects.
Viagra is the brand name for the drug sildenafil, which works by increasing blood flow to the penis. Cialis, on the other hand, is a brand name for tadalafil, which is a phosphodiesterase type 5 (PDE5) inhibitor.
“If you look at the results, there were no significant differences in terms of side effects between the two medications,” Zuckerman said. “In the study, the incidence of adverse events was higher for patients taking Viagra and Cialis compared to those taking the other medication.”
Cialis and Viagra are the only OTC medications that have been approved for use in the U. for ED. The study was funded by Pfizer Inc.
“The fact that Viagra and Cialis were taken together in combination is interesting,” Zuckerman said. “We think that combining these two medications may have increased the risk of serious adverse events.”
The study was conducted by the U. National Institutes of Health and was published online in the journal
The researchers analyzed data from 1,000 men who were prescribed over-the-counter ED medication and 1,000 men who were prescribed Cialis and tadalafil for ED in the U. The researchers analyzed data from 1,020 men who had received the medications for a period of four weeks.
“Based on the results, it's clear that taking these medications together may be associated with increased risks for serious adverse events,” Zuckerman said.
The researchers said they did not take the two medications together because they thought they had similar side effects. They did not conduct separate analyses on the risk of side effects from Viagra or Cialis.
Viagra and Cialis are both PDE5 inhibitors.
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Cialis (tadalafil) can interact with certain foods and beverages, such as those containing taurine, which may reducet your blood pressure by relaxing the blood vessels in the treatment of erectile dysfunction.
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Levitra is a drug developed by the pharmaceutical company Viatris. Levitra works by increasing blood flow to the penis, which helps men to achieve and maintain an erection. Levitra is used to treat erectile dysfunction (ED) in men. Levitra is one of the popular drugs in Europe and has been the main focus of many pharmaceutical companies. Levitra is a phosphodiesterase type 5 (PDE5) inhibitor that works by inhibiting the PDE5 enzyme in the body. Levitra is a member of the class of drugs known as phosphodiesterase type 5 inhibitors, which are used to treat erectile dysfunction. The Levitra dosage and frequency is adjusted according to your medical condition and response to treatment.
Levitra may be used to treat:
Levitra is an FDA-approved drug for the treatment of ED. The main active ingredient in Levitra isVardenafil. It is a PDE5 inhibitor that relaxes blood vessels and increases the blood flow to the penis. When sexual stimulation causes blood to flow into the penis, Levitra works by increasing blood flow to the penis. Levitra is one of the most commonly used drugs in Europe, but there is some side effects. Common side effects of Levitra include:
Levitra is a PDE5 inhibitor. It works by relaxing the blood vessels in the penis, which increases blood flow. Levitra is a member of the PDE5 inhibitors, which are used to treat erectile dysfunction in men. Levitra is available in tablet form and the dosage and frequency are adjusted according to your medical condition and response to treatment. Levitra is a member of the PDE5 inhibitors. The generic version of Levitra is also available in tablet form and the medication is available in various strengths.
Levitra is an FDA-approved drug for the treatment of erectile dysfunction (ED).Sildenafil CitrateThe dosage and frequency of Levitra is adjusted according to your medical condition and response to treatment. Levitra is an effective treatment for ED, and it can be used as needed to treat ED. It works by increasing blood flow to the penis and helping men to achieve and maintain an erection.
If you are a man who has ED, you should be able to enjoy sex with a partner who is able to perform sexually. However, it can cause many problems if you do not have a partner.
Levitra is an FDA-approved drug for the treatment of erectile dysfunction (ED) in men.
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